Relationship of Mutation of Kodon S 315 T katG Mycobaterium Tuberculosis Gene with Multidrug Resistance Tuberculosis in South Sumatera
نویسندگان
چکیده
منابع مشابه
Isoniazid resistance and the point mutation of codon 463 of katG gene of Mycobacterium tuberculosis.
It has long been known that almost all isoniazid (INH) resistant mycobacteria lose the catalase and peroxidase activities along with reduced or no virulence for guinea pigs. Recently resistance to INH has become known to be associated with mutations of katG gene encoding the HPI (Hydroperoxidase I) type catalase and peroxidase. Among these mutations, the point mutation of codon 463 of katG gene...
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Objective(s) Isoniazid (INH) is one of the main first line drugs used in treatment of tuberculosis and development of resistance against this compound can result in serious problems in treatment procedures. Resistance to INH is mediated mainly by mutation in KatG gene that is coded for the catalase enzyme. The proportional method for detection of INH-resistance is time consuming due to the slo...
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متن کاملIdentification and analysis of mutations in the katG gene in multidrug-resistant Mycobacterium tuberculosis clinical isolates.
INTRODUCTION A major role in the development of resistance of Mycobacterium tuberculosis to isoniazid (INH) is attributed to mutations in the katG gene coding for the catalase/peroxidase, an enzyme required for obtaining a pharmacologically active form of the drug. Analysis of mutations in the katG gene in M. tuberculosis strains may contribute to the development of reliable and rapid tests for...
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ژورنال
عنوان ژورنال: Biomedical Journal of Indonesia
سال: 2020
ISSN: 2685-0184,2407-7097
DOI: 10.32539/bji.v6i1.10187